+220.532, +71 in T.I. Anche se dovremmo essere vicini al picco, dati veramente brutti.
La mia umile stazione meteo
https://www.wunderground.com/dashboard/pws/IREGGI57
Il problema è che questi dati potrebbero anche aggiornarli ogni 30 secondi, ma siccome le regioni li comunicano ormai letteralmente a ondate, perché non riescono a inserirli e perché molte asl sono letteralmente ingolfate dai referti di positività, comunicati da farmacie e laboratori privati, siamo arrivati alla situazione paradossale per cui questo computo non han quasi più senso... da notare ad esempio come la Liguria oggi abbia caricato gli esiti di quasi 47.000 tamponi (oltre 2 volte e mezzo la media quotidiana tenuta nell'ultimo mese)... di questi oltre 32.000 sono antigenici, immagino quasi tutti tutti tamponi di controllo fatti per il fine quarantena oppure tamponi diagnostici di persone che aspettavano da giorni la diagnosi (qualcuno da prima di Natale, ne ho contezza diretta...), considerando che l'ordinanza regionale ha avuto effetto da ieri immagino si andrà avanti così per almeno una settimana.. in compenso a livello regionale calano i ricoveri in area non critica (-11) e restano stabili quelli in uti, c'erano stati timidi segnali di rallentamento, speriamo che il saldo negativo dei ricoveri si mantenga nei prossimi giorni e si consolidi.
Ultima modifica di galinsog@; 11/01/2022 alle 19:54
Lombardia, terza dose: dal 18 gennaio possibile il cambio data - Cronaca, Bergamo
Sono commossa... finalmente anch'io lombarda potrò anticipare la dose senza cancellare la prenotazione precedente!
Praticamente, dal 24 al 18 di gennaio, ben 6 giorni di possibile anticipo!!! (prenotazione fatta subito, illo tempore, quando ancora la davano a 6 mesi...)
FAVOLA DELLA BUONA NOTTE @burian br @Perlecano @barry e tutti gli interessati. Non taggo il prof. Bassetti perchè ci metterebbe una settimana a capire che significa binding e nn se lo può permettere deve badare al suo reparto
As SARS-CoV-2 began its global spread, Starr and Bloom realized that fitness landscapes provided a useful way to begin studying the novel pathogen. It gave them a way to figure out what factors were important in viral proteins and how much change the virus could tolerate.Initially, scientists sequencing SARS-CoV-2 didn’t notice much genetic variation. Although coronaviruses use an error-prone RNA polymerase to copy their genetic material, SARS-CoV-2 has a second protein that acts as a proofreader. So researchers didn’t expect the virus to acquire as many mutations as, say, influenza or HIV.Bloom and Starr knew that the spike protein would be the part of the coronavirus under the most intense evolutionary pressure because it is what the immune system recognizes most strongly and what the virus uses to break into the body’s cells. With 1,273 amino acids, however, the spike protein is too sizable for rapid evaluation by a fitness landscape. Starr therefore decided to focus on a subsection of the spike protein known as the receptor binding domain, which is just a few hundred amino acids — a much more tractable problem.Starr used deep mutational scanning to create 4,000 different mutations of the receptor binding domain. He evaluated their ability to bind to the human ACE2 protein (the molecular “lock” it picks to enter cells) and to be recognized by the immune system. If SARS-CoV-2 couldn’t tolerate much variation in its receptor binding domain, Starr expected to see that the immune recognition or ACE2-binding functions would be severely compromised by mutations.But that’s not at all what happened. “The receptor binding domain had a lot of different mutations that actually improved binding affinity,” Starr said. “This looked like a really tolerant domain that had a lot of capacity to evolve. Yet the mindset at the time was that coronaviruses don’t evolve antigenically. They were probably going to be stable.”While the receptor binding domain tolerated more variation than expected, not all parts of the spike protein did. These parts of the spike protein may therefore be good targets for new vaccines and monoclonal antibodies, Starr says, since they are less likely to mutate over time.When they first posted these results on the biorxiv.org preprint server in June 2020, it was a huge wake-up call, Starr says — one of the first indications that SARS-CoV-2 was more mutable than people thought. Now Starr and Bloom are repeating their deep mutational scanning experiments on the alpha, beta, gamma, delta and omicron variants to gain similar insights about their receptor binding domains.Starr, Bloom and colleagues also created a map of all the possible mutations to the receptor binding domain that didn’t interfere with ACE2 binding. Their work, published in Science in January 2021, identified potential mutations in this domain that could evade neutralization by monoclonal antibody therapies. Their work also identified several mutations that emerged in an immunocompromised individual who was infected with SARS-CoV-2 for 150 days. By the time this person received monoclonal antibody treatment at day 145, they had already developed resistance to the available products on the market. To Starr, this showed that these therapeutic monoclonal antibodies could become less effective over time, either within a single patient or more generally as the virus mutates.Moreover, as Starr, Bloom and their colleagues described last summer in Nature Communications, several widespread mutations can each help SARS-CoV-2 evade some of the antibodies that the immune system typically directs against the most targeted parts of the receptor binding domain. So far, no viral lineage has evolved to have all three of these mutations. “However, we suggest the appearance of such a variant would be a worrying development and should be monitored closely,” they wrote.The world in which SARS-CoV-2 first emerged at the end of 2019 was different from the world of today. The ability of the virus to produce lots of copies of itself and to spread between individuals was surely key to its success early in the pandemic. As the number of people immunized through vaccination and naturally acquired infection rises, however, the virus will experience more pressure to evade immune responses. Lauring says many mutations come with trade-offs, and SARS-CoV-2 is no exception. An immune escape variant with reduced virus transmission might not have been favored in early 2020, but it might be now.“We’re the environment for the virus,” Lauring said. “If we change, the landscape changes.”
il lockdown senza una effettiva dichiarazione . Gente messa in isolamento che magari non ha nulla . quarantene che non hanno mai termine perchè non le fanno terminare . questo è lo scenario attuale non le TI o ricoveri . stanno creando un problema dove non dovrebbe esserci .
Ho dovuto cambiare la macchina e la ragazza : una succhiava troppo e una troppo poco e aggiungo ..
Stazione Meteo Urbana Udine Sud . Lacrosse 2300 in schermo ventilato 24h autocostruito http://ramandolo.homeunix.net/
L'intera famiglia di mio cugino contagiata, ma stanno tutti bene, anche anziani pluripatologici. Se non è il vaccino vorrà dire che è un covid decisamente meno preoccupante delle prime "versioni", chiamiamole così.
IMG_20220111_213935_456.jpg
Nonostante il record di casi segnali positivi se si guarda il numero di contagi rispetto a martedí scorso. Inaspettatamente anche in Piemonte.
Aumentano ancora a ritmo sostenuto Bolzano, Puglia, Molise, Sicilia e Campania, ma tutte le altre sembrano rallentare
Segnalibri