One potential hypothesis scientists are looking into is that children were less exposed to these common viruses while COVID-19 restrictions were in place, preventing social mixing. Now, as things open up and children begin mixing again, they are suddenly being exposed to a number of viruses in quick succession and their immune systems are over-responding, which eventually leads to inflammation of the liver.Though most of the children who have had the mystery hepatitis have been under age five, some have been older and this theory, though widely reported, does not carry substance for them as they are likely to have been exposed to adenoviruses when they were younger – before the pandemic began.



Another possible hypothesis is that a prior infection with the SARS-CoV-2 virus could be linked to the rise in cases of hepatitis in children. Some, though not all, of the children in the UK who were diagnosed with hepatitis tested positive for COVID; the theory being looked into asks whether a previous or current infection with COVID-19 could make children more susceptible to hepatitis when then infected with an adenovirus. While isolated cases of hepatitis have been reported in patients with severe COVID, this is rare.


DOMANDA: nel secondo caso (ipotesi covid) si sono considerate solo le infezioni attive oppure hanno fatto l'indagine per capire se tutti gli altri sono mai venuti a contatto col virus?