Nuovo Virus Cinese

[Alexander]

Hai tutta la mia comprensione, lo dico sinceramente, ed essendo uno dei 3 che scrive solo fatti dalla Svizzera, perché ci vivo, ti dò il mio più totale incoraggiamento a usare il tasto ignora su di me (se non già fatto)

Grazie dell'incoraggiamento kima, ma decido io chi mettere in ignore list, e fino ad oggi è successo solo una volta.
Dopo vent'anni e passa che frequento forum ho imparato a distinguere tra chi partecipa positivamente alle discussioni arricchendole mantenendo un comportamento non arrogante e presuntuoso con cui è piacevole confrontarsi (ed è il tuo caso) e chi invece scatena post volutamente provocatori, nascondendosi dietro poemi filosofeggianti e ricchi di belle parole ma che nascondono ben altri intenti. Per non parlare poi dei magheggi dei dati per portare avanti le proprie convinzioni strampalate e con cui nemmeno perdo il tempo di controbattere.
Ma ogni tanto mi permetto di intervenire, come stasera, perché dopo un po' anche basta. Basta pagine e pagine di litigi, flames e argomenti che oltre a essere fuori tema non interessano a nessuno, e qui lo ripeto.
Già hanno abbandonato il topic parecchi utenti perché stremati da queste continue infinite e ripetitive discussioni non trovavano più gli argomenti IT e si è obbligati a scorrere decine di pagine per trovare qualcosa inerente al tema.

[verza81]

È più di qualche giorno che Roma è completamente fuori scala, avete idea del perché?
IMG_7936.jpg


Inviato dal mio iPhone utilizzando Tapatalk

[ale97]

Quando potrà uscire di casa probabilmente lo farà per buttarsi sotto un treno
O in alternativa in carcere per aver violato la quarantena


Si scherza ovviamente, ma fino a un certo punto....


Covid: vive in isolamento da 14 mesi e risulta ancora positivo dopo 78 test - Il Mattino.it

[ale97]

Sì, ci può stare. Però senza restrizioni in generale il virus gira di più a monte, quindi diventa più probabile il contagio familiare. Non è un caso che adesso in relazione lì abbiano molti più contagi che da noi…

Va beh dai, non le considererei proprio restrizioni anche le nostre. Praticamente cambia solo la procedura per le quarantene, il GP (che lato contagi non ha più grandissima influenza come con Alpha è Delta) e pochissimi altri dettagli rispetto a tutti gli altri Stati.

Direi che dipende quasi esclusivamente dal numero di vaccinati, poi comunque non è così vero che non ci sia più un bacino di suscettibili (ma questo lo hai specificato tu stesso)

[Musoita]

As BA.2 subvariant of Omicron rises, lab studies point to signs of severity


he BA.2 virus -- a subvariant of the Omicron coronavirus variant -- isn't just spreading faster than its distant cousin, it may also cause more severe disease and appears capable of thwarting some of the key weapons we have against Covid-19, new research suggests.

New lab experiments from Japan show that BA.2 may have features that make it as capable of causing serious illness as older variants of Covid-19, including Delta.
And like Omicron, it appears to largely escape the immunity created by vaccines. A booster shot restores protection, making illness after infection about 74% less likely.
BA.2 is also resistant to some treatments, including sotrovimab, the monoclonal antibody that's currently being used against Omicron.




The findings were posted Wednesday as a preprint study on the bioRxiv server, before peer review. Normally, before a study is published in medical journal, it is scrutinized by independent experts. Preprints allow research to be shared more quickly, but they are posted before that additional layer of review.
"It might be, from a human's perspective, a worse virus than BA.1 and might be able to transmit better and cause worse disease," says Dr. Daniel Rhoads, section head of microbiology at the Cleveland Clinic in Ohio. Rhoads reviewed the study but was not involved in the research.
BA.2 is highly mutated compared with the original Covid-causing virus that emerged in Wuhan, China. It also has dozens of gene changes that are different from the original Omicron strain, making it as distinct from the most recent pandemic virus as the Alpha, Beta, Gamma and Delta variants were from each other.
Kei Sato, a researcher at the University of Tokyo who conducted the study, argues that these findings prove that BA.2 should not be considered a type of Omicron and that it needs to be more closely monitored.




"As you may know, BA.2 is called 'stealth Omicron,' " Sato told CNN. That's because it doesn't show up on PCR tests as an S-gene target failure, the way Omicron does. Labs therefore have to take an extra step and sequence the virus to find this variant.
"Establishing a method to detect BA.2 specifically would be the first thing" many countries need to do, he says.
"It looks like we might be looking at a new Greek letter here," agreed Deborah Fuller, a virologist at the University of Washington School of Medicine, who reviewed the study but was not part of the research.
Mixed real-world data on subvariant's severity


BA.2 is about 30% to 50% more contagious than Omicron. It has been detected in 74 countries and 47 US states.
The US Centers for Disease Control and Prevention estimates that about 4% of Americans with Covid-19 now have infections caused by BA.2, but many other parts of the world have more experience with this variant. It has become dominant in at least 10 other countries: Bangladesh, Brunei, China, Denmark, Guam, India, Montenegro, Nepal, Pakistan and the Philippines, according to World Health Organization's weekly epidemiological report.
But, there's mixed evidence on the severity of BA.2 in the real world. Hospitalizations continue to decline in countries where BA.2 has gained a foothold, like South Africa and the UK. But in Denmark, where BA.2 has become the leading cause of infections, hospitalizations and deaths are rising, according to WHO.

Resistant to monoclonal antibody treatments


The new study found that BA.2 can copy itself in cells more quickly than BA.1, the original version of Omicron. It's also more adept at causing cells to stick together. This allows the virus to create larger clumps of cells, called syncytia, than BA.1. That's concerning because these clumps then become factories for churning out more copies of the virus. Delta was also good at creating syncytia, which is thought to be one reason it was so destructive to the lungs.
When the researchers infected hamsters with BA.2 and BA.1, the animals infected with BA.2 got sicker and had worse lung function. In tissues samples, the lungs of BA.2-infected hamsters had more damage than those infected by BA.1.



Similar to the original Omicron, BA.2 was capable of breaking through antibodies in the blood of people who'd been vaccinated against Covid-19. It was also resistant to the antibodies of people who'd been infected with Covid-19 early in the pandemic, including Alpha and Delta. And BA.2 was almost completely resistant to some monoclonal antibody treatments.
But there was a bright spot: Antibodies in the blood of people who'd recently had Omicron also seemed to have some protection against BA.2, especially if they'd also been vaccinated.
And that raises an important point, Fuller says. Even though BA.2 seems more contagious and pathogenic than Omicron, it may not wind up causing a more devastating wave of Covid-19 infections.
"One of the caveats that we have to think about as we get new variants that might seem more dangerous is the fact that there's two sides to the story," Fuller says.





The virus matters, she says, but as its would-be hosts, so do we.
"Our immune system is evolving as well. And so that's pushing back on things," she said.
Right now, she says, we're in a race against the virus, and the key question is, who's in the lead?
"What we will ultimately want is to have the host be ahead of the virus. In other words, our immunity, be a step ahead of the next variant that comes out, and I don't know that we're quite there yet," she said.
For that reason, Fuller says, she feels like it's not quite time for communities to lift mask mandates.
"Before this thing came out, we were about 10 feet away from the finish line," she said. "Taking off the masks now is not a good idea. It's just going to extend it. Let's get to the finish line."

[AbeteBianco]

Grazie dell'incoraggiamento kima, ma decido io chi mettere in ignore list, e fino ad oggi è successo solo una volta.
Dopo vent'anni e passa che frequento forum ho imparato a distinguere tra chi partecipa positivamente alle discussioni arricchendole mantenendo un comportamento non arrogante e presuntuoso con cui è piacevole confrontarsi (ed è il tuo caso) e chi invece scatena post volutamente provocatori, nascondendosi dietro poemi filosofeggianti e ricchi di belle parole ma che nascondono ben altri intenti. Per non parlare poi dei magheggi dei dati per portare avanti le proprie convinzioni strampalate e con cui nemmeno perdo il tempo di controbattere.
Ma ogni tanto mi permetto di intervenire, come stasera, perché dopo un po' anche basta. Basta pagine e pagine di litigi, flames e argomenti che oltre a essere fuori tema non interessano a nessuno, e qui lo ripeto.
Già hanno abbandonato il topic parecchi utenti perché stremati da queste continue infinite e ripetitive discussioni non trovavano più gli argomenti IT e si è obbligati a scorrere decine di pagine per trovare qualcosa inerente al tema.

Concordo, anche perché ho notato in prima persona varie volte che commenti fatti allo scopo di promuovere un confronto di idee su vari temi o fatti (come dovrebbe funzionare in un luogo civile a beneficio di tutti…) debbano poi essere travisati da alcuni per generale flames, attacchi, o addirittura opinioni diverse vengono percepite come offese, o via anche a dare dei novax a chi non si allinea ad una certa linea presumibilmente condivisa da una maggioranza (forse mica vero), e mai riflettere su cosa ci sia di altro. Avendo un po’ di esperienza in ciò posso tranquillamente affermare che non tutti sono in grado di partecipare ad un dibattito.
Non pensavo si arrivasse a questi livelli ma l’ho notato in queste settimane, veramente peccato.

[burian br]

Quando potrà uscire di casa probabilmente lo farà per buttarsi sotto un treno
O in alternativa in carcere per aver violato la quarantena


Si scherza ovviamente, ma fino a un certo punto....


Covid: vive in isolamento da 14 mesi e risulta ancora positivo dopo 78 test - Il Mattino.it

Non sarebbe la prima volta nel caso.
Non so se conoscete la storia:

Mary Mallon - Wikipedia

[FunMBnel]

Quindi teniamo tutti in scacco ad oltranza perché i parenti degli sfigati non usano alcuna precauzione?
Ma anca no..

L'essenza della democrazia è che decide sì la maggioranza, ma è fondamentale la tutela delle minoranze, specie se deboli.
Dopo 2 anni continuo a vedere questo atteggiamento (che in altri campi dura da molto più tempo) modello giungla in cui tutti si credono leoni. Ribadisco che vorrei proprio vederlo.
E non sto ovviamente parlando dei cialtroni no-vax.

[Gianni78ba]

As BA.2 subvariant of Omicron rises, lab studies point to signs of severity


he BA.2 virus -- a subvariant of the Omicron coronavirus variant -- isn't just spreading faster than its distant cousin, it may also cause more severe disease and appears capable of thwarting some of the key weapons we have against Covid-19, new research suggests.

New lab experiments from Japan show that BA.2 may have features that make it as capable of causing serious illness as older variants of Covid-19, including Delta.
And like Omicron, it appears to largely escape the immunity created by vaccines. A booster shot restores protection, making illness after infection about 74% less likely.
BA.2 is also resistant to some treatments, including sotrovimab, the monoclonal antibody that's currently being used against Omicron.




The findings were posted Wednesday as a preprint study on the bioRxiv server, before peer review. Normally, before a study is published in medical journal, it is scrutinized by independent experts. Preprints allow research to be shared more quickly, but they are posted before that additional layer of review.
"It might be, from a human's perspective, a worse virus than BA.1 and might be able to transmit better and cause worse disease," says Dr. Daniel Rhoads, section head of microbiology at the Cleveland Clinic in Ohio. Rhoads reviewed the study but was not involved in the research.
BA.2 is highly mutated compared with the original Covid-causing virus that emerged in Wuhan, China. It also has dozens of gene changes that are different from the original Omicron strain, making it as distinct from the most recent pandemic virus as the Alpha, Beta, Gamma and Delta variants were from each other.
Kei Sato, a researcher at the University of Tokyo who conducted the study, argues that these findings prove that BA.2 should not be considered a type of Omicron and that it needs to be more closely monitored.




"As you may know, BA.2 is called 'stealth Omicron,' " Sato told CNN. That's because it doesn't show up on PCR tests as an S-gene target failure, the way Omicron does. Labs therefore have to take an extra step and sequence the virus to find this variant.
"Establishing a method to detect BA.2 specifically would be the first thing" many countries need to do, he says.
"It looks like we might be looking at a new Greek letter here," agreed Deborah Fuller, a virologist at the University of Washington School of Medicine, who reviewed the study but was not part of the research.
Mixed real-world data on subvariant's severity


BA.2 is about 30% to 50% more contagious than Omicron. It has been detected in 74 countries and 47 US states.
The US Centers for Disease Control and Prevention estimates that about 4% of Americans with Covid-19 now have infections caused by BA.2, but many other parts of the world have more experience with this variant. It has become dominant in at least 10 other countries: Bangladesh, Brunei, China, Denmark, Guam, India, Montenegro, Nepal, Pakistan and the Philippines, according to World Health Organization's weekly epidemiological report.
But, there's mixed evidence on the severity of BA.2 in the real world. Hospitalizations continue to decline in countries where BA.2 has gained a foothold, like South Africa and the UK. But in Denmark, where BA.2 has become the leading cause of infections, hospitalizations and deaths are rising, according to WHO.

Resistant to monoclonal antibody treatments


The new study found that BA.2 can copy itself in cells more quickly than BA.1, the original version of Omicron. It's also more adept at causing cells to stick together. This allows the virus to create larger clumps of cells, called syncytia, than BA.1. That's concerning because these clumps then become factories for churning out more copies of the virus. Delta was also good at creating syncytia, which is thought to be one reason it was so destructive to the lungs.
When the researchers infected hamsters with BA.2 and BA.1, the animals infected with BA.2 got sicker and had worse lung function. In tissues samples, the lungs of BA.2-infected hamsters had more damage than those infected by BA.1.



Similar to the original Omicron, BA.2 was capable of breaking through antibodies in the blood of people who'd been vaccinated against Covid-19. It was also resistant to the antibodies of people who'd been infected with Covid-19 early in the pandemic, including Alpha and Delta. And BA.2 was almost completely resistant to some monoclonal antibody treatments.
But there was a bright spot: Antibodies in the blood of people who'd recently had Omicron also seemed to have some protection against BA.2, especially if they'd also been vaccinated.
And that raises an important point, Fuller says. Even though BA.2 seems more contagious and pathogenic than Omicron, it may not wind up causing a more devastating wave of Covid-19 infections.
"One of the caveats that we have to think about as we get new variants that might seem more dangerous is the fact that there's two sides to the story," Fuller says.





The virus matters, she says, but as its would-be hosts, so do we.
"Our immune system is evolving as well. And so that's pushing back on things," she said.
Right now, she says, we're in a race against the virus, and the key question is, who's in the lead?
"What we will ultimately want is to have the host be ahead of the virus. In other words, our immunity, be a step ahead of the next variant that comes out, and I don't know that we're quite there yet," she said.
For that reason, Fuller says, she feels like it's not quite time for communities to lift mask mandates.
"Before this thing came out, we were about 10 feet away from the finish line," she said. "Taking off the masks now is not a good idea. It's just going to extend it. Let's get to the finish line."

Quando la prima decade di febbraio 2020 cominciò a formarsi il rapporto del 2% tra casi e morti a livello mondiale tale rapporto si è poi mantenuto fino all'esordio della omicron. Ora a 2 mesi e mezzo dalla sua ribalta il rapporto si è quasi dimezzato.
Secondo me avremo concreti segnali se dovesse invertire la rotta. Semplicemente guardando quel rapporto avremo una prima idea di quello che sta succedendo.

[simo89]

Non sarebbe la prima volta nel caso.
Non so se conoscete la storia:

Mary Mallon - Wikipedia

Che storia!

Vabbè dai però questa è una scema...cioè capisco all'epoca la mancanza di conoscenza scientifica minima da parte delle persone, ma una volta che ti dicono puoi contagiare gli altri, e tu continui a fare come ti pare, cioè...